Alpha-1-Antitrypsin (SERPINA1) Antibody
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935106861
info@markelab.com
Precio
364€ (100 µg)
Antibody anti-SERPINA1
proveedor
Abbexareference
abx230338Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Human, Ratstatus
RUOclonality
MonoclonalDescripción
Alpha-1-Antitrypsin Antibody is a Mouse Monoclonal against Alpha-1-Antitrypsin.
Background
The SERPINA1 gene, commonly known as alpha-1 antitrypsin (A1AT), encodes a protein that plays a crucial role in protecting tissues from enzymes of inflammatory cells, particularly neutrophil elastase. This gene is part of the serine protease inhibitor (serpin) superfamily and is located on chromosome 14 (14q32.13). Alpha-1 antitrypsin is primarily synthesized in the liver, although it is also produced in smaller quantities by other tissues, including the lungs, intestines, and kidneys. The protein encoded by SERPINA1 is a glycoprotein that circulates in the blood and functions as a major inhibitor of proteases, especially neutrophil elastase, which, if left unchecked, can degrade elastin and other extracellular matrix components, leading to tissue damage.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human, Rat
immunogen target
Alpha-1-Antitrypsin (SERPINA1)
host
Mouse
isotype
IgG1
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purity
≥ 95% (SDS-PAGE)
purification
Purified by Protein A and Protein G affinity chromatography.
recommended dilution
WB: 1/500 - 1/5000, IHC: 1/500 - 1/1000, IF/ICC: 1/20 - 1/200, IP: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SERPINA1
dry ice
No
availability
Shipped within 5-12 working days.
alias
PI,A1A,AAT; PI1,A1AT,nNIF,PRO2275,alpha1AT,Alpha-1-antitrypsin,Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Serpin A1
uniprot id
note
Concentration: 2 mg/ml - Validity: 12 months.
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