Alpha-1-Antitrypsin (SERPINA1) Antibody

Name: Alpha-1-Antitrypsin (SERPINA1) Antibody
Brand: Abbexa
SKU: abx000959
Price: 195 EUR
Availability: OnlineOnly

Este producto es parte de SERPINA1 - serpin family A member 1

Pida mas información

935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-SERPINA1

proveedor

Abbexa

reference

abx000959

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

SERPINA1 Antibody is a Rabbit Polyclonal antibody against SERPINA1. The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Background

The SERPINA1 gene, commonly known as alpha-1 antitrypsin (A1AT), encodes a protein that plays a crucial role in protecting tissues from enzymes of inflammatory cells, particularly neutrophil elastase. This gene is part of the serine protease inhibitor (serpin) superfamily and is located on chromosome 14 (14q32.13). Alpha-1 antitrypsin is primarily synthesized in the liver, although it is also produced in smaller quantities by other tissues, including the lungs, intestines, and kidneys. The protein encoded by SERPINA1 is a glycoprotein that circulates in the blood and functions as a major inhibitor of proteases, especially neutrophil elastase, which, if left unchecked, can degrade elastin and other extracellular matrix components, leading to tissue damage.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Alpha-1-Antitrypsin (SERPINA1)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, IF/ICC

purification

Purified by affinity chromatography.

recommended dilution

ELISA: 1 µg/ml, WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

size 1

20 µl

size 2

100 µl

size 3

2 × 100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SERPINA1

dry ice

availability

Shipped within 5-10 working days.

alias

PI,A1A,AAT; PI1,A1AT,nNIF,PRO2275,alpha1AT,Alpha-1-antitrypsin,Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Serpin A1

uniprot id

https://www.uniprot.org/uniprotkb/P01009

gene id

https://www.ncbi.nlm.nih.gov/gene/5265

NCBI accession

NP_000286.3

note

Concentration: > 0.2 mg/ml -

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