Alkaline Phosphatase, Placental Type (ALPP) Antibody

Este producto es parte de ALPP - Alkaline phosphatase germ cell type (Placental)
Alkaline Phosphatase, Placental Type (ALPP) Antibody

Pida mas información

935106861

info@markelab.com

Precio

292.5€ (80 µl)

Antibody anti-ALPP

proveedor

Abbexa

reference

abx028430

Tested Applications

ELISA, WB, IHC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.


Background

Alkaline phosphatase, germ cell type (ALPP) is an enzyme that is predominantly expressed in germ cells, which are the cells that give rise to sperm and eggs. ALPP is also known as germ cell alkaline phosphatase (GCAP).GCAP is a type of alkaline phosphatase that is specifically expressed in germ cells during spermatogenesis and oogenesis. It plays a role in the development and maturation of germ cells, although its exact function in this process is not fully understood. GCAP is sometimes used as a marker for germ cell tumors. These tumors originate from germ cells and can occur in various locations in the body, including the testes, ovaries, and extragonadal sites. Elevated levels of GCAP in the blood or other bodily fluids may indicate the presence of germ cell tumors. GCAP is also used as a marker for identifying the presence of germ cells in certain tissues, such as testicular biopsies or embryonic stem cell cultures, where the presence of germ cells is of interest for research or diagnostic purposes.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Alkaline Phosphatase, Placental Type (ALPP)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purification

Purified through a protein A column, followed by peptide affinity purification.


recommended dilution

WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS containing 0.09% sodium azide.


size 1

80 µl


size 2

400 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ALPP


dry ice

No


availability

Shipped within 5-10 working days.


alias

ALPP,PLAP


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