Alkaline Phosphatase, Placental Type (ALPP) Antibody
292.5€ (80 µl)
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935106861
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name
Alkaline Phosphatase, Placental Type (ALPP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025392
tested applications
ELISA, WB
Description
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alkaline Phosphatase, Placental Type (ALPP) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05187 |
| Alias | ALPP,PLAP |
| Background | Antibody anti-ALPP |
| Status | RUO |
Descripción
Alkaline phosphatase, germ cell type (ALPP) is an enzyme that is predominantly expressed in germ cells, which are the cells that give rise to sperm and eggs. ALPP is also known as germ cell alkaline phosphatase (GCAP).GCAP is a type of alkaline phosphatase that is specifically expressed in germ cells during spermatogenesis and oogenesis. It plays a role in the development and maturation of germ cells, although its exact function in this process is not fully understood. GCAP is sometimes used as a marker for germ cell tumors. These tumors originate from germ cells and can occur in various locations in the body, including the testes, ovaries, and extragonadal sites. Elevated levels of GCAP in the blood or other bodily fluids may indicate the presence of germ cell tumors. GCAP is also used as a marker for identifying the presence of germ cells in certain tissues, such as testicular biopsies or embryonic stem cell cultures, where the presence of germ cells is of interest for research or diagnostic purposes.
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