Aldosterone (ALD) Antibody
390€ (100 µl)
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Name
Aldosterone (ALD) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx411069
Tested Applications
ELISA
Description
Aldosterone (ALD) Antibody is a Sheep Polyclonal antibody against Aldosterone (ALD).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldosterone (ALD) Immunogen: Aldosterone conjugated to BSA. |
| Host | Sheep |
| Reactivity | General |
| Assay Type | Concentration: 5.0 mg/ml |
| Recommended Dilution | ELISA: 1/300 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | PBS. Contains 0.09% sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Aldocorten,Aldocortin |
| Background | Antibody anti-ALD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Aldosterone is a steroid hormone synthesized in the zona glomerulosa of the adrenal cortex and plays a critical role in the regulation of electrolyte balance and blood pressure it acts on mineralocorticoid receptors in the kidneys to increase sodium reabsorption and potassium excretion in the distal tubules and collecting ducts this sodium retention leads to water retention contributing to blood volume and pressure maintenance aldosterone secretion is primarily regulated by the renin-angiotensin-aldosterone system (RAAS) as well as potassium levels and adrenocorticotropic hormone (ACTH) dysregulation of aldosterone can lead to conditions such as primary hyperaldosteronism (Conn's syndrome) characterized by hypertension and hypokalemia and hypoaldosteronism which can result in hyperkalemia and hypotension aldosterone measurement is crucial in diagnosing these conditions with techniques such as ELISA and CLIA commonly used to quantify its levels in plasma research into aldosterone antagonists is ongoing for the treatment of resistant hypertension and heart failure where aldosterone plays a pathological role in promoting fibrosis and vascular dysfunction
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