Aldosterone (ALD) Antibody

Background

Aldosterone is a steroid hormone synthesized in the zona glomerulosa of the adrenal cortex and plays a critical role in the regulation of electrolyte balance and blood pressure it acts on mineralocorticoid receptors in the kidneys to increase sodium reabsorption and potassium excretion in the distal tubules and collecting ducts this sodium retention leads to water retention contributing to blood volume and pressure maintenance aldosterone secretion is primarily regulated by the renin-angiotensin-aldosterone system (RAAS) as well as potassium levels and adrenocorticotropic hormone (ACTH) dysregulation of aldosterone can lead to conditions such as primary hyperaldosteronism (Conn's syndrome) characterized by hypertension and hypokalemia and hypoaldosteronism which can result in hyperkalemia and hypotension aldosterone measurement is crucial in diagnosing these conditions with techniques such as ELISA and CLIA commonly used to quantify its levels in plasma research into aldosterone antagonists is ongoing for the treatment of resistant hypertension and heart failure where aldosterone plays a pathological role in promoting fibrosis and vascular dysfunction