Aldose Reductase (AKR1B1) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Aldose Reductase (AKR1B1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211260
Tested Applications
ELISA, WB, IHC
Description
AKR1B1 Antibody is a Rabbit Polyclonal against AKR1B1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldose Reductase (AKR1B1) Immunogen: Synthetic peptide of human AKR1B1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15121 |
| Gene ID | 231 |
| NCBI Accession | NP_001619.1 |
| OMIM | 103880 |
| Alias | AKR1B1,ADR ALDR1,ALR2,AR |
| Background | Antibody anti-AKR1B1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR1B1, also known as aldose reductase, is a key enzyme in the polyol pathway that converts glucose to sorbitol under hyperglycemic conditions. It has a significant role in the pathogenesis of diabetic complications, such as neuropathy, nephropathy, and retinopathy, as sorbitol accumulation induces osmotic stress and oxidative damage. AKR1B1 also metabolizes reactive aldehydes, including lipid peroxidation products like 4-hydroxynonenal (4-HNE), contributing to cellular detoxification under oxidative stress. Its overactivation under diabetic and inflammatory conditions exacerbates oxidative stress and inflammatory signaling pathways. AKR1B1 inhibitors have been developed as potential therapeutic agents for managing diabetic complications. Beyond diabetes, AKR1B1 is involved in steroid metabolism and the detoxification of xenobiotics. It has also been implicated in cancer progression, as its expression is upregulated in some tumors, promoting proliferation and chemoresistance by reducing reactive aldehydes and maintaining cellular redox balance.
Productos relacionados
Aldose Reductase (AKR1B1) Antibody
AKR1B1 Antibody is a Rabbit Polyclonal antibody against AKR1B1. This gene encodes a member of the aldo/keto reductase su…
Ver producto
Aldose Reductase (AKR1B1) Antibody
Rabbit polyclonal antibody against AKR1B1 protein. Immunogen region is C-terminal.…
Ver producto Aldose Reductase (AKR1B1) Antibody
AR Antibody is a Mouse Monoclonal antibody against AR.…
Ver producto