Aldose Reductase (AKR1B1) Antibody

Este producto es parte de AKR1B - Aldo-keto reductase family 1 member B
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Aldose Reductase (AKR1B1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031673
tested applications
ELISA, WB, IHC, IF/ICC

Description

AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.

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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAldose Reductase (AKR1B1)
HostRabbit
ReactivityHuman
Recommended DilutionWB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified Rabbit Polyclonal Antibody.
Size 180 µl
Size 2400 µl
FormLiquid
Tested ApplicationsELISA, WB, IHC, IF/ICC
BufferPBS containing 0.09% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP15121
Gene ID231
NCBI AccessionNP_001619.1
OMIM103880
AliasAKR1B1,ADR ALDR1,ALR2,AR
BackgroundAntibody anti-AKR1B1
StatusRUO

Descripción

AKR1B1, also known as aldose reductase, is a key enzyme in the polyol pathway that converts glucose to sorbitol under hyperglycemic conditions. It has a significant role in the pathogenesis of diabetic complications, such as neuropathy, nephropathy, and retinopathy, as sorbitol accumulation induces osmotic stress and oxidative damage. AKR1B1 also metabolizes reactive aldehydes, including lipid peroxidation products like 4-hydroxynonenal (4-HNE), contributing to cellular detoxification under oxidative stress. Its overactivation under diabetic and inflammatory conditions exacerbates oxidative stress and inflammatory signaling pathways. AKR1B1 inhibitors have been developed as potential therapeutic agents for managing diabetic complications. Beyond diabetes, AKR1B1 is involved in steroid metabolism and the detoxification of xenobiotics. It has also been implicated in cancer progression, as its expression is upregulated in some tumors, promoting proliferation and chemoresistance by reducing reactive aldehydes and maintaining cellular redox balance.

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