Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Antibody
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Description
Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Antibody is a Rabbit polyclonal antibody for the detection of Human Aldo-Keto Reductase Family 1 Member C3 (AKR1C3).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Immunogen: Recombinant Aldo-Keto Reductase Family 1 Member C3 (Met1-Tyr323) expressed in E. coli. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C for up to 2 weeks. For long-term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42330 |
| Gene ID | 8644 |
| NCBI Accession | NP_001240837.1 |
| Alias | AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS |
| Background | Antibody anti-AKR1C3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
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