Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Antibody
169€ (20 µg)
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Name
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx109512
Tested Applications
ELISA, WB
Description
Aldo-keto reductase family 1 member C2 Antibody is a Rabbit Polyclonal antibody against Aldo-keto reductase family 1 member C2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Immunogen: Recombinant human Aldo-keto reductase family 1 member C2 protein (1-323AA). |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52895 |
| Gene ID | 1646 |
| NCBI Accession | NP_001128713.1, NM_001135241.2 |
| OMIM | 600450 |
| Alias | AKR1C2,DDH2 |
| Background | Antibody anti-AKR1C2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR1C2, known as 3α-hydroxysteroid dehydrogenase, catalyzes the reduction of 5α-dihydrotestosterone (DHT) to 3α-androstanediol, thereby inactivating this potent androgen. AKR1C2 is a key regulator of androgen and neurosteroid metabolism, playing a crucial role in modulating androgen signaling in tissues such as the prostate, brain, and liver. Dysregulation of AKR1C2 is associated with androgen-driven diseases, including prostate cancer, where its activity can suppress DHT levels and attenuate androgen receptor signaling. AKR1C2 also metabolizes progesterone and other steroid intermediates, linking it to reproductive and neuroendocrine functions. Its role in neurosteroid metabolism influences processes like synaptic inhibition, neuroprotection, and stress responses in the brain. Overexpression of AKR1C2 has been reported in cancers and drug-resistant tumors, where it contributes to detoxifying reactive carbonyl species and reducing chemotherapeutic efficacy. As a result, AKR1C2 is considered a therapeutic target for prostate cancer and neurodegenerative disorders.
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