Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody
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Description
Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human, Mouse, Rat ALDH2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase, Mitochondrial (ALDH2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05091 |
| Alias | ALDH2,ALDM,ALDH class 2 |
| Background | Antibody anti-ALDH2 |
| Status | RUO |
Descripción
ALDH2 is a mitochondrial enzyme primarily responsible for the oxidation of acetaldehyde, a toxic intermediate produced during ethanol metabolism, into acetate. It plays a key role in alcohol detoxification, protecting cells from acetaldehyde-induced toxicity, which can lead to DNA damage, lipid peroxidation, and oxidative stress. ALDH2 also detoxifies reactive aldehydes generated during lipid peroxidation, such as 4-hydroxynonenal (4-HNE), and participates in mitochondrial redox balance. A common mutation in the ALDH2 gene, known as ALDH2*2, reduces enzymatic activity and is prevalent in East Asian populations, leading to alcohol intolerance, increased cancer risk (e.g., esophageal cancer), and cardiovascular diseases. ALDH2 is also protective against ischemic heart injury, as it reduces oxidative damage during cardiac stress. Its role in aldehyde detoxification and mitochondrial function highlights ALDH2 as a therapeutic target for alcohol-related diseases, cancer prevention, and cardiovascular disorders.
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anti- ALDH2 antibody
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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