Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody
234€ (5 µg)
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Name
Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137544
Description
Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody is a Mouse Monoclonal antibody against Aldehyde Dehydrogenase, Mitochondrial (ALDH2).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase, Mitochondrial (ALDH2) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | ALDH2,ALDM,ALDH class 2 |
| Background | Antibody anti-ALDH2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH2 is a mitochondrial enzyme primarily responsible for the oxidation of acetaldehyde, a toxic intermediate produced during ethanol metabolism, into acetate. It plays a key role in alcohol detoxification, protecting cells from acetaldehyde-induced toxicity, which can lead to DNA damage, lipid peroxidation, and oxidative stress. ALDH2 also detoxifies reactive aldehydes generated during lipid peroxidation, such as 4-hydroxynonenal (4-HNE), and participates in mitochondrial redox balance. A common mutation in the ALDH2 gene, known as ALDH2*2, reduces enzymatic activity and is prevalent in East Asian populations, leading to alcohol intolerance, increased cancer risk (e.g., esophageal cancer), and cardiovascular diseases. ALDH2 is also protective against ischemic heart injury, as it reduces oxidative damage during cardiac stress. Its role in aldehyde detoxification and mitochondrial function highlights ALDH2 as a therapeutic target for alcohol-related diseases, cancer prevention, and cardiovascular disorders.
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