Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody
442€ (200 µl)
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935106861
info@markelab.com
name
Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431088
tested applications
P-ELISA, WB
Description
ALDH2 Antibody is a Goat Polyclonal antibody against ALDH2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Immunogen: abx616282 - Internal region: C-DETQFKKILGYIN |
| Host | Goat |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 217, 11669, 29539 |
| NCBI Accession | NP_000681.2, NP_001191818.1 |
| Alias | ALDH2,ALDM,ALDH class 2 |
| Background | Antibody anti-ALDH2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ALDH2 is a mitochondrial enzyme primarily responsible for the oxidation of acetaldehyde, a toxic intermediate produced during ethanol metabolism, into acetate. It plays a key role in alcohol detoxification, protecting cells from acetaldehyde-induced toxicity, which can lead to DNA damage, lipid peroxidation, and oxidative stress. ALDH2 also detoxifies reactive aldehydes generated during lipid peroxidation, such as 4-hydroxynonenal (4-HNE), and participates in mitochondrial redox balance. A common mutation in the ALDH2 gene, known as ALDH2*2, reduces enzymatic activity and is prevalent in East Asian populations, leading to alcohol intolerance, increased cancer risk (e.g., esophageal cancer), and cardiovascular diseases. ALDH2 is also protective against ischemic heart injury, as it reduces oxidative damage during cardiac stress. Its role in aldehyde detoxification and mitochondrial function highlights ALDH2 as a therapeutic target for alcohol-related diseases, cancer prevention, and cardiovascular disorders.
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