Aldehyde Dehydrogenase 9 Family, Member A1 (ALDH9A1) Antibody
416€ (200 µl)
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935106861
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name
Aldehyde Dehydrogenase 9 Family, Member A1 (ALDH9A1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432311
tested applications
P-ELISA, WB, IHC
Description
ALDH9A1 Antibody is a Goat Polyclonal antibody against ALDH9A1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 9 Family, Member A1 (ALDH9A1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 223 |
| NCBI Accession | NP_000687.3 |
| Alias | ALDH9A1,ALDH4,ALDH7,ALDH9 |
| Background | Antibody anti-ALDH9A1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
ALDH9A1 is a cytosolic enzyme that oxidizes γ-aminobutyraldehyde (GABAL) and betaine aldehyde to their respective acids, playing a role in neurotransmitter metabolism and osmolyte synthesis. It is highly expressed in the liver, brain, and kidneys, where it supports the conversion of GABAL to GABA, an important inhibitory neurotransmitter, and the conversion of betaine aldehyde to betaine, a key osmolyte involved in cellular hydration and methylation processes. ALDH9A1’s function is critical for maintaining GABA homeostasis, osmotic balance, and methyl group donation in metabolic pathways. Dysregulation of ALDH9A1 has been associated with neurological disorders, where impaired GABA metabolism can contribute to excitotoxicity and neurodegeneration. ALDH9A1 also protects cells from aldehyde toxicity, as it detoxifies reactive intermediates generated during amino acid and lipid metabolism. Its role in neurotransmitter balance and cellular protection makes it a target for neurological and metabolic disease therapies.
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