Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx334663
Description
ALDH7A1 Antibody (FITC) is a Rabbit Polyclonal against ALDH7A1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49419 |
| Gene ID | 501 |
| Alias | ALDH7A1,ATQ1 |
| Background | Antibody anti-ALDH7A1 |
| Status | RUO |
Descripción
ALDH7A1, also known as antiquitin, is a multifunctional enzyme involved in lysine catabolism and aldehyde detoxification. It catalyzes the oxidation of α-aminoadipic semialdehyde to α-aminoadipate, a key step in the lysine degradation pathway. Mutations in ALDH7A1 cause pyridoxine-dependent epilepsy (PDE), a rare inherited disorder characterized by seizures that are responsive to vitamin B6 (pyridoxine) supplementation. ALDH7A1 deficiency leads to the accumulation of toxic intermediates, such as α-aminoadipic semialdehyde, which interfere with neurotransmitter function and neuronal health. ALDH7A1 also plays a role in detoxifying aldehydes generated during lipid peroxidation and oxidative stress, protecting tissues from damage. Its expression in the liver, brain, and kidneys highlights its importance in amino acid metabolism, energy production, and cellular defense against aldehyde toxicity.
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