Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Antibody
299€ (100 µl)
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935106861
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name
Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104358
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALDH7A1,ATQ1 |
| Background | Antibody anti-ALDH7A1 |
| Status | RUO |
Descripción
ALDH7A1, also known as antiquitin, is a multifunctional enzyme involved in lysine catabolism and aldehyde detoxification. It catalyzes the oxidation of α-aminoadipic semialdehyde to α-aminoadipate, a key step in the lysine degradation pathway. Mutations in ALDH7A1 cause pyridoxine-dependent epilepsy (PDE), a rare inherited disorder characterized by seizures that are responsive to vitamin B6 (pyridoxine) supplementation. ALDH7A1 deficiency leads to the accumulation of toxic intermediates, such as α-aminoadipic semialdehyde, which interfere with neurotransmitter function and neuronal health. ALDH7A1 also plays a role in detoxifying aldehydes generated during lipid peroxidation and oxidative stress, protecting tissues from damage. Its expression in the liver, brain, and kidneys highlights its importance in amino acid metabolism, energy production, and cellular defense against aldehyde toxicity.
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