Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) Antibody
455€ (100 µl)
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Name
Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx159324
Tested Applications
ELISA, WB
Description
ALDH3A2 Antibody is a Mouse Monoclonal against ALDH3A2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) Immunogen: Purified recombinant human ALDH3A2 protein fragments expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat, Rabbit |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51648 |
| Alias | ALDH3A2,ALDH10,FALDH |
| Background | Antibody anti-ALDH3A2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH3A2, also known as fatty aldehyde dehydrogenase (FALDH), is a key enzyme that catalyzes the oxidation of fatty aldehydes to fatty acids. This process is essential for lipid metabolism, particularly in the breakdown of long-chain and very-long-chain fatty aldehydes derived from sphingolipids and dietary fats. Mutations in ALDH3A2 cause Sjögren-Larsson Syndrome (SLS), a rare autosomal recessive disorder characterized by ichthyosis (skin scaling), spasticity, and intellectual disability due to the accumulation of fatty aldehydes and disruption of lipid homeostasis. ALDH3A2 is expressed in the liver, brain, and skin, where it supports lipid metabolism and protects against oxidative stress. Its role in maintaining cellular membrane integrity and energy balance highlights its importance in metabolic and neuroprotective functions. Therapies targeting ALDH3A2 aim to restore fatty acid metabolism and alleviate symptoms of SLS, emphasizing its role in lipid-mediated pathologies.
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