Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) Antibody
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Description
ALDH3A2 Antibody is a Mouse Monoclonal against ALDH3A2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat, Rabbit |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51648 |
| Alias | ALDH3A2,ALDH10,FALDH |
| Background | Antibody anti-ALDH3A2 |
| Status | RUO |
Descripción
ALDH3A2, also known as fatty aldehyde dehydrogenase (FALDH), is a key enzyme that catalyzes the oxidation of fatty aldehydes to fatty acids. This process is essential for lipid metabolism, particularly in the breakdown of long-chain and very-long-chain fatty aldehydes derived from sphingolipids and dietary fats. Mutations in ALDH3A2 cause Sjögren-Larsson Syndrome (SLS), a rare autosomal recessive disorder characterized by ichthyosis (skin scaling), spasticity, and intellectual disability due to the accumulation of fatty aldehydes and disruption of lipid homeostasis. ALDH3A2 is expressed in the liver, brain, and skin, where it supports lipid metabolism and protects against oxidative stress. Its role in maintaining cellular membrane integrity and energy balance highlights its importance in metabolic and neuroprotective functions. Therapies targeting ALDH3A2 aim to restore fatty acid metabolism and alleviate symptoms of SLS, emphasizing its role in lipid-mediated pathologies.
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