Aldehyde Dehydrogenase 1 Family Member A2 (ALDH1A2) Antibody

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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169€ (20 µg)

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935106861
info@markelab.com
name
Aldehyde Dehydrogenase 1 Family Member A2 (ALDH1A2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx318156
tested applications
ELISA, WB, IHC

Description

ALDH1A2 Antibody is a Rabbit Polyclonal against ALDH1A2.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAldehyde Dehydrogenase 1 Family Member A2 (ALDH1A2)
HostRabbit
ReactivityHuman, Mouse
Recommended DilutionWB: 1/500 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Tested ApplicationsELISA, WB, IHC
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDO94788
Gene ID8854
NCBI AccessionNP_001193826.1, NM_001206897.1, NP_003879.2, NM_003888.3
OMIM603687
AliasRALDH 2,RalDH2,Retinaldehyde specific dehydrogenase type 2
BackgroundAntibody anti-ALDH1A2
StatusRUO

ALDH1A2, like ALDH1A1, catalyzes the conversion of retinaldehyde to retinoic acid, a critical molecule for regulating gene expression during embryonic development and organogenesis. ALDH1A2 is highly expressed during early development, particularly in tissues forming the heart, lungs, and nervous system, where it regulates retinoic acid signaling pathways essential for proper patterning and differentiation. Loss-of-function mutations in ALDH1A2 lead to congenital disorders, including congenital diaphragmatic hernia, cardiac anomalies, and craniofacial defects, due to disrupted retinoic acid gradients during development. In adults, ALDH1A2 plays a role in maintaining tissue homeostasis and regulating inflammatory responses. Its dysregulation has been linked to metabolic disorders, such as obesity and insulin resistance, as well as fibrotic diseases. ALDH1A2 is also studied in cancer biology for its role in tumor growth suppression through retinoic acid-mediated differentiation and cell cycle control.

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