Alcohol Dehydrogenase 1 (ADH1) Antibody
273€ (100 µl)
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935106861
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name
Alcohol Dehydrogenase 1 (ADH1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx102313
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Alcohol Dehydrogenase 1 (ADH1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alcohol Dehydrogenase 1 (ADH1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00329 |
| Gene ID | 11522 |
| Alias | ADH1 |
| Background | Antibody anti-ADH1A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADH1A is a member of the alcohol dehydrogenase (ADH) family, specifically the alpha subunit of the class I ADH enzymes, which are expressed primarily in the liver and gastrointestinal tract. These enzymes catalyze the oxidation of alcohols to aldehydes, playing a central role in the metabolism of ethanol and other substrates such as retinol and hydroxysteroids. ADH1A contributes to the initial step of alcohol metabolism, enabling the conversion of ethanol into acetaldehyde, which is subsequently metabolized by aldehyde dehydrogenase. Its expression is critical for detoxification and energy production pathways. Genetic polymorphisms in ADH1A can affect enzyme activity, influencing an individual's alcohol tolerance and susceptibility to alcohol-related diseases such as liver cirrhosis and alcohol dependence. Beyond ethanol metabolism, ADH1A is also involved in retinoid metabolism, highlighting its broader role in cellular signaling and development.
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