Alanine Glyoxylate Aminotransferase (AGXT) Antibody
292.5€ (200 µl)
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Name
Alanine Glyoxylate Aminotransferase (AGXT) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx431826
Tested Applications
P-ELISA
Description
AGXT Antibody is a Goat Polyclonal antibody against AGXT.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alanine Glyoxylate Aminotransferase (AGXT) Immunogen: abx615768 - Internal region: C-DKAKSKVYSRKTK |
| Host | Goat |
| Reactivity | Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 24792 |
| NCBI Accession | NP_085914.1 |
| Alias | AGXT, AGT1, SPAT |
| Background | Antibody anti-AGXT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Alanine-glyoxylate aminotransferase (AGXT) is a pyridoxal phosphate-dependent enzyme localized in peroxisomes, where it plays a critical role in detoxifying glyoxylate by converting it into glycine, using alanine as an amino donor. AGXT is central to preventing the overproduction of oxalate, a byproduct of glyoxylate metabolism, which, if accumulated, can form calcium oxalate crystals leading to kidney stones and renal damage. Mutations in the AGXT gene cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by excessive oxalate production, kidney stone formation, and systemic oxalosis. AGXT's activity is regulated by intracellular localization and metabolic cues, and therapies targeting AGXT include enzyme replacement therapy and gene therapy to restore glyoxylate metabolism in affected individuals.
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