Aflibercept

Descripción

Aflibercept is a recombinant fusion protein biosimilar expressed in CHO cells, targeting VEGFA, Aflibercept is a manufactured protein that acts as a decoy receptor for all VEGF-A isoforms and placental growth factor. This agent was engineered through fusion of the ligand-binding domains from two VEGF receptors with the constant region of IgG1, resulting in high-affinity VEGF binding and prevention of VEGF pathway activation.