Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) Antibody
169€ (20 µl)
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Name
Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx322501
Tested Applications
ELISA, WB, IHC
Description
AKR7A2 Antibody is a Rabbit Polyclonal against AKR7A2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aflatoxin B1 Aldehyde Reductase Member 2 (AKR7A2) Immunogen: Recombinant human Aflatoxin B1 aldehyde reductase member 2 protein (100-359AA). |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43488 |
| Gene ID | 8574 |
| OMIM | 603418 |
| Alias | AKR7A2,AFAR,AFAR1,AKR7 |
| Background | Antibody anti-AKR7A2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR7A2 is a member of the aldo-keto reductase superfamily that plays a central role in detoxifying harmful aldehydes, including those generated from reactive oxygen species (ROS) and environmental toxins. It specifically reduces aflatoxin B1-dialdehyde, a highly toxic metabolite produced from aflatoxin exposure, into its less reactive alcohol form, protecting cells from aflatoxin-induced damage. AKR7A2 is highly expressed in the liver, kidneys, and gastrointestinal tract, where it safeguards against toxic metabolites arising from dietary toxins, such as aflatoxins, and endogenous lipid peroxidation products like 4-hydroxynonenal (4-HNE). It is also involved in detoxifying aldehydes produced during ethanol metabolism, linking it to alcohol-induced liver injury prevention. AKR7A2 has antioxidant properties that help maintain cellular redox balance under oxidative stress. Dysregulation of AKR7A2 can lead to increased susceptibility to aflatoxin-induced liver carcinogenesis, as inefficient detoxification exacerbates DNA damage and mutagenesis. Recent studies highlight its potential as a protective factor against environmental toxins and as a therapeutic target for liver disease prevention.
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