AFF1-Specific Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
AFF1-Specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230195
tested applications
ELISA, WB, IHC, IF/ICC
Description
AFF1-Specific Antibody is a Rabbit Polyclonal against AFF1-Specific.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AFF1-Specific |
| Host | Rabbit |
| Reactivity | Human, rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51825 |
| Alias | AF4,FEL,MLLT2,PBM1 |
| Background | Antibody anti-AFF1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
The AFF (AF4/FMR2) family member refers to a group of proteins associated with various cellular functions, particularly in the context of gene regulation and transcriptional control. The name "AFF" comes from the fusion partner of MLL (Mixed-Lineage Leukemia) in certain leukemia cases, where AFF1, also known as AF4, is one of the fusion partners. AFF1 (AF4) is a protein implicated in chromosomal translocations that result in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). It's known to be involved in transcriptional elongation and regulation. The AF4 protein itself is associated with the super elongation complex (SEC), which plays a role in regulating RNA polymerase II elongation.
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