Adrenocorticotropic Hormone Receptor (MC2R) Antibody
442€ (200 µl)
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935106861
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name
Adrenocorticotropic Hormone Receptor (MC2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430265
tested applications
P-ELISA, WB
Description
MC2R Antibody is a Goat Polyclonal antibody against MC2R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Adrenocorticotropic Hormone Receptor (MC2R) Immunogen: abx615402 - N-Terminus: ENINNTARNNSDC |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4158 |
| NCBI Accession | NP_000520.1 |
| Alias | MC2R,ACTHR,melanocortin 2 receptor,adrenocorticotropic hormone receptor,melanocortin 2 receptor (adrenocorticotropic hormone) |
| Background | Antibody anti-MC2R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
MC2R, also known as the adrenocorticotropic hormone receptor, is a G protein-coupled receptor specifically activated by adrenocorticotropic hormone (ACTH). MC2R is primarily expressed in the adrenal cortex, where it regulates the synthesis and release of glucocorticoids, such as cortisol, in response to ACTH binding. Upon activation, MC2R couples to Gs proteins, stimulating adenylyl cyclase and increasing cAMP levels, which activate protein kinase A (PKA). This signaling cascade drives steroidogenesis by upregulating key enzymes involved in cortisol production. MC2R is essential for maintaining the hypothalamic-pituitary-adrenal (HPA) axis, which controls the body’s response to stress, inflammation, and metabolism. Dysregulation of MC2R signaling is linked to conditions such as Addison’s disease (adrenal insufficiency), Cushing’s syndrome (excess cortisol), and ACTH resistance syndromes. Mutations in MC2R can impair cortisol production, leading to glucocorticoid deficiencies. Targeting MC2R and ACTH pathways offers therapeutic opportunities for managing adrenal disorders and inflammatory conditions involving glucocorticoid regulation.
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