Adrenocorticotropic Hormone Receptor (MC2R) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
MC2R Antibody is a Goat Polyclonal antibody against MC2R.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adrenocorticotropic Hormone Receptor (MC2R) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4158 |
| NCBI Accession | NP_000520.1 |
| Alias | MC2R,ACTHR,melanocortin 2 receptor,adrenocorticotropic hormone receptor,melanocortin 2 receptor (adrenocorticotropic hormone) |
| Background | Antibody anti-MC2R |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
MC2R, also known as the adrenocorticotropic hormone receptor, is a G protein-coupled receptor specifically activated by adrenocorticotropic hormone (ACTH). MC2R is primarily expressed in the adrenal cortex, where it regulates the synthesis and release of glucocorticoids, such as cortisol, in response to ACTH binding. Upon activation, MC2R couples to Gs proteins, stimulating adenylyl cyclase and increasing cAMP levels, which activate protein kinase A (PKA). This signaling cascade drives steroidogenesis by upregulating key enzymes involved in cortisol production. MC2R is essential for maintaining the hypothalamic-pituitary-adrenal (HPA) axis, which controls the body’s response to stress, inflammation, and metabolism. Dysregulation of MC2R signaling is linked to conditions such as Addison’s disease (adrenal insufficiency), Cushing’s syndrome (excess cortisol), and ACTH resistance syndromes. Mutations in MC2R can impair cortisol production, leading to glucocorticoid deficiencies. Targeting MC2R and ACTH pathways offers therapeutic opportunities for managing adrenal disorders and inflammatory conditions involving glucocorticoid regulation.
Related Products
Adrenocorticotropic Hormone Receptor (MC2R) Antibody
MC2R Antibody is a Rabbit Polyclonal antibody against MC2R. MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
Ver Producto
Adrenocorticotropic Hormone Receptor (ACTHR) Antibody
Rabbit polyclonal antibody against ACTHR protein. Immunogen region is C-terminal.
Ver Producto
Rat Adrenocorticotropic Hormone Receptor (ACTHR) ELISA Kit
Rat Adrenocorticotropic Hormone Receptor (ACTHR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Adrenocorticotropic Hormone Receptor (ACTHR) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ACTHR (ACTHR)
Ver Producto