Adrenergic Receptor Beta 3 (ADRB3) Antibody (FITC)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ADRB3 Antibody (FITC) is a Rabbit Polyclonal against ADRB3 conjugated to FITC.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adrenergic Receptor Beta 3 (ADRB3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13945 |
| Gene ID | 155 |
| OMIM | 109691 |
| Alias | ADRB3,atypical β-adrenoceptor,ADRB,Adrb-3,beta 3-AR,BETA3AR |
| Background | Antibody anti-ADRB3 |
| Status | RUO |
| Note | Concentration: 0.25 mg/ml - |
Descripción
The adrenergic receptor beta-3 (ADRB3) is a member of the beta-adrenergic receptor family, which is primarily expressed in adipose tissue, particularly brown and white fat, as well as in the bladder and vascular tissues. This G-protein-coupled receptor (GPCR) plays a critical role in regulating lipolysis and thermogenesis by activating adenylate cyclase through the Gs protein. Upon stimulation by catecholamines like norepinephrine and epinephrine, ADRB3 enhances energy expenditure, making it a key target in the management of obesity and metabolic syndrome. Its involvement in thermogenesis is mediated through the activation of uncoupling protein 1 (UCP1) in brown adipose tissue, which dissipates energy as heat. Polymorphisms in the ADRB3 gene, such as the Trp64Arg variant, have been associated with altered receptor activity, contributing to metabolic conditions like obesity, insulin resistance, and type 2 diabetes. Additionally, ADRB3 is implicated in bladder relaxation, making it a therapeutic target for overactive bladder syndrome. Its dual role in energy metabolism and smooth muscle relaxation underscores its significance in systemic metabolic regulation and pharmaceutical research.
Related Products
Adrenergic Receptor Beta 3 (ADRB3) Antibody
ADRB3 Antibody is a Rabbit Polyclonal Antibody against ADRB3.
Ver Producto
Mouse Adrenergic Receptor Beta 3 (ADRB3) ELISA Kit
Mouse Adrenergic Receptor Beta 3 (ADRB3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Adrenergic Receptor beta 3 (ADRb3) concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Adrenergic Receptor Beta 3 (ADRb3)
Ver Producto
Rat Adrenergic Receptor Beta 3 (ADRB3) ELISA Kit
Rat Adrenergic Receptor Beta 3 (ADRB3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Adrenergic Receptor beta 3 (ADRb3) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Adrenergic Receptor Beta 3 (ADRb3)
Ver Producto