Adrb3 (Intracellular) Antibody
292.5€ (200 µl)
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name
Adrb3 (Intracellular) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431082
tested applications
P-ELISA, IHC
Description
Adrb3 (Intracellular) Antibody is a Goat Polyclonal antibody against Adrb3 (Intracellular).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Adrb3 (Intracellular) Immunogen: abx616719 - Internal region (near C-Terminus): C-EARQSPPLNRFD |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 155, 11556, 25645 |
| NCBI Accession | NP_038490.2 |
| Alias | ADRB3,atypical β-adrenoceptor,ADRB,Adrb-3,beta 3-AR,BETA3AR |
| Background | Antibody anti-ADRB3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The adrenergic receptor beta-3 (ADRB3) is a member of the beta-adrenergic receptor family, which is primarily expressed in adipose tissue, particularly brown and white fat, as well as in the bladder and vascular tissues. This G-protein-coupled receptor (GPCR) plays a critical role in regulating lipolysis and thermogenesis by activating adenylate cyclase through the Gs protein. Upon stimulation by catecholamines like norepinephrine and epinephrine, ADRB3 enhances energy expenditure, making it a key target in the management of obesity and metabolic syndrome. Its involvement in thermogenesis is mediated through the activation of uncoupling protein 1 (UCP1) in brown adipose tissue, which dissipates energy as heat. Polymorphisms in the ADRB3 gene, such as the Trp64Arg variant, have been associated with altered receptor activity, contributing to metabolic conditions like obesity, insulin resistance, and type 2 diabetes. Additionally, ADRB3 is implicated in bladder relaxation, making it a therapeutic target for overactive bladder syndrome. Its dual role in energy metabolism and smooth muscle relaxation underscores its significance in systemic metabolic regulation and pharmaceutical research.
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