ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2 (ARFGEF2) Antibody

Background

ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) is a guanine nucleotide exchange factor (GEF) that activates ADP-ribosylation factor (ARF) proteins, playing a key role in regulating cellular processes such as vesicular trafficking, actin cytoskeleton remodeling, and signal transduction ARFGEF2 promotes the exchange of GDP for GTP on ARF proteins, thus facilitating their activation and enabling the regulation of processes like vesicle formation, endocytosis, and the organization of cell membranes ARFGEF2 also regulates actin dynamics, contributing to cell migration, morphology, and division It plays a significant role in the immune system, where it influences immune cell trafficking and activation Dysregulation of ARFGEF2 has been associated with diseases such as cancer, where abnormal ARF and actin dynamics contribute to tumor cell migration and metastasis Additionally, ARFGEF2 is involved in the regulation of metabolic processes, and its dysfunction can lead to metabolic disorders, immune diseases, and cancer