Adenylate Kinase 5 (AK5) Antibody
357.5€ (100 µg)
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Name
Adenylate Kinase 5 (AK5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037892
Tested Applications
ELISA, IHC
Description
Rabbit Polyclonal against the AK5 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenylate Kinase 5 (AK5) Immunogen: A peptide corresponding to the internal region of Human AK5 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_174858 |
| Alias | AK6 |
| Background | Antibody anti-AK5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AK5 is a cytosolic adenylate kinase predominantly expressed in the brain, where it plays a role in neural energy metabolism and synaptic function. Unlike other AK isoforms, AK5 demonstrates substrate specificity for ATP/GTP and AMP. It is thought to regulate energy transfer and storage in neurons, particularly in response to neurotransmission demands. AK5 expression correlates with cognitive functions, and its dysfunction has been implicated in neurodevelopmental disorders and memory deficits. AK5 has been shown to influence energy-sensing pathways, such as AMPK, thereby contributing to neuronal survival during energy depletion.
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