Adenosylhomocysteinase (AHCY) Antibody
819€ (1 ml)
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935106861
info@markelab.com
name
Adenosylhomocysteinase (AHCY) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx171083
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenosylhomocysteinase (AHCY) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | SAHH,adoHcyase |
| Background | Antibody anti-AHCY |
| Status | RUO |
Descripción
AHCY, also known as S-adenosylhomocysteine hydrolase, is a critical enzyme in the methionine cycle that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) into homocysteine and adenosine. This reaction is essential for maintaining cellular methylation reactions, as SAH is a potent inhibitor of methyltransferases. AHCY is ubiquitously expressed and localized in the cytoplasm and nucleus, where it regulates methylation-dependent processes such as DNA and histone modification, gene expression, and cell signaling. Dysregulation of AHCY leads to the accumulation of SAH, disrupting methylation and contributing to diseases such as homocystinuria, cardiovascular disease, and neurodegenerative disorders. Mutations in the AHCY gene can cause autosomal recessive hypermethioninemia. AHCY is also being studied as a potential target in cancer and metabolic disorders due to its pivotal role in methylation homeostasis.
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Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
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