Adenosylhomocysteinase (AHCY) Antibody
637€ (100 µl)
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Name
Adenosylhomocysteinase (AHCY) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx115369
Tested Applications
ELISA, WB, IHC
Description
S-Adenosylhomocysteine Hydrolase Antibody is a Rabbit Polyclonal antibody against S-Adenosylhomocysteine Hydrolase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenosylhomocysteinase (AHCY) Immunogen: Human AHCY. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23526 |
| Gene ID | 191 |
| NCBI Accession | NP_000678.1, NM_000687.3 |
| OMIM | 180960 |
| Alias | SAHH,adoHcyase |
| Background | Antibody anti-AHCY |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AHCY, also known as S-adenosylhomocysteine hydrolase, is a critical enzyme in the methionine cycle that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) into homocysteine and adenosine. This reaction is essential for maintaining cellular methylation reactions, as SAH is a potent inhibitor of methyltransferases. AHCY is ubiquitously expressed and localized in the cytoplasm and nucleus, where it regulates methylation-dependent processes such as DNA and histone modification, gene expression, and cell signaling. Dysregulation of AHCY leads to the accumulation of SAH, disrupting methylation and contributing to diseases such as homocystinuria, cardiovascular disease, and neurodegenerative disorders. Mutations in the AHCY gene can cause autosomal recessive hypermethioninemia. AHCY is also being studied as a potential target in cancer and metabolic disorders due to its pivotal role in methylation homeostasis.
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