Adenosylhomocysteinase (AHCY) Antibody
364€ (100 µg)
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Name
Adenosylhomocysteinase (AHCY) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230227
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
AHCY Antibody is a Mouse Monoclonal against AHCY.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Adenosylhomocysteinase (AHCY) Immunogen: S-adenosylhomocysteine hydrolase |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Observed MW | Observed MW: 48 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23526 |
| Alias | SAHH,adoHcyase |
| Background | Antibody anti-AHCY |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AHCY, also known as S-adenosylhomocysteine hydrolase, is a critical enzyme in the methionine cycle that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) into homocysteine and adenosine. This reaction is essential for maintaining cellular methylation reactions, as SAH is a potent inhibitor of methyltransferases. AHCY is ubiquitously expressed and localized in the cytoplasm and nucleus, where it regulates methylation-dependent processes such as DNA and histone modification, gene expression, and cell signaling. Dysregulation of AHCY leads to the accumulation of SAH, disrupting methylation and contributing to diseases such as homocystinuria, cardiovascular disease, and neurodegenerative disorders. Mutations in the AHCY gene can cause autosomal recessive hypermethioninemia. AHCY is also being studied as a potential target in cancer and metabolic disorders due to its pivotal role in methylation homeostasis.
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