Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110814
tested applications
ELISA, WB
Description
Acyl-Coenzyme Adehydrogenase, Long Chain(Acadl) Antibody is a Rabbit Polyclonal antibody against Acyl-Coenzyme Adehydrogenase, Long Chain(Acadl).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Ammonium Sulfate Precipitation. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28330 |
| Gene ID | 33 |
| OMIM | 609576 |
| Alias | ACAD4,LCAD |
| Background | Antibody anti-ACADL |
| Status | RUO |
Descripción
ACADL , also known as long-chain acyl-CoA dehydrogenase (LCAD), is a mitochondrial enzyme critical for the β-oxidation of long-chain fatty acids. It catalyzes the first step in the oxidative breakdown of long-chain fatty acyl-CoAs, facilitating their conversion into energy through the tricarboxylic acid (TCA) cycle and electron transport chain. ACADL is predominantly expressed in energy-demanding tissues such as the liver, heart, and skeletal muscle, where fatty acid metabolism is essential for maintaining energy homeostasis during fasting and sustained physical activity. Dysregulation or mutations in the ACADL gene can result in long-chain acyl-CoA dehydrogenase deficiency, a rare metabolic disorder characterized by hypoglycemia, muscle weakness, and lipid accumulation due to impaired fatty acid oxidation. ACADL also plays a role in lipid signaling and mitochondrial health, contributing to cellular responses to metabolic stress. Its enzymatic activity underscores its importance in energy metabolism, lipid regulation, and mitochondrial function, making it a key target for studies on metabolic diseases and energy balance.
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anti- ACADL antibody
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anti- ACADL-Specific antibody
ACADL(Long-chain specific acyl-CoA dehydrogenase, mitochondrial) is also named as LCAD and belongs to the acyl-CoA dehydrogenase family.It catalyzes the first reaction of the mitochondrial β-oxidation of fatty acids and is synthesized in the cytosol as a precursor that is larger than its mature from. The size difference between the precursor and mature rat LCAD has been estimated to be 3 kDa on the basis of SDS-PAGE(PMID:1774065).Defects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency(ACADVLD).
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