Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) Antibody (FITC)
169€ (20 µg)
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name
Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx306374
Description
ACSL4 Antibody (FITC) is a Rabbit Polyclonal against ACSL4 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60488 |
| Gene ID | 2182 |
| NCBI Accession | NP_001305438.1, NM_001318509.1 |
| OMIM | 300157 |
| Alias | ACS4,FACL4,LACS4 MRX63,MRX68 |
| Background | Antibody anti-ACSL4 |
| Status | RUO |
Descripción
ACSL4 is an acyl-CoA synthetase with a strong preference for polyunsaturated fatty acids, such as arachidonic and docosahexaenoic acids, converting them into acyl-CoA derivatives for metabolic use. It is highly expressed in the brain, testis, and adrenal glands, where it supports processes requiring specialized lipid metabolism, including the biosynthesis of eicosanoids and membrane lipids. ACSL4 is critical in ferroptosis, a type of programmed cell death triggered by lipid peroxidation, through its role in incorporating polyunsaturated fatty acids into phospholipids. Dysregulation of ACSL4 has been linked to cancer, neurodegenerative diseases, and inflammatory disorders, as it influences processes such as oxidative stress and cellular survival. Its specific role in handling polyunsaturated fatty acids highlights its importance in maintaining cellular lipid balance and preventing oxidative damage under stress conditions.
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ACSL4 Antibody is a Rabbit Polyclonal antibody against ACSL4. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
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