ACVR1 Antibody (Biotin)

416€ (200 µl)
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935106861
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name
ACVR1 Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx431072
tested applications
P-ELISA, WB
Description
ACVR1 Antibody is a Goat Polyclonal antibody against ACVR1 (
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | ACVR1 |
Host | Goat |
Reactivity | Human |
Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Biotin |
Isotype | IgG |
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Size 1 | 200 µl |
Form | Liquid |
Tested Applications | P-ELISA, WB |
Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
Availability | Shipped within 1-3 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Gene ID | 90, 11477, 79558 |
NCBI Accession | NP_001096.1 |
Alias | ACVRLK2 |
Background | Antibody anti-ACVR1 |
Status | RUO |
Note | Concentration: 0.5 mg/ml - |
Descripción
ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.
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