Activity Dependent Neuroprotector Protein (ADNP) Antibody
357.5€ (100 µg)
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Name
Activity Dependent Neuroprotector Protein (ADNP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038425
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the ADNP protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Activity Dependent Neuroprotector Protein (ADNP) Immunogen: A peptide corresponding to the C-terminal region of human ADNP protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 124 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_015339 |
| Alias | ADNP, ADNP1, KIAA0784,HVDAS, MRD28 |
| Background | Antibody anti-ADNP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Activity-dependent neuroprotector homeobox protein (ADNP) is a transcription factor and neuroprotective protein essential for brain development, neurogenesis, and chromatin remodeling through interactions with SWI/SNF chromatin-remodeling complexes It regulates gene expression critical for maintaining neuronal survival, synaptic plasticity, and cognitive processes Mutations or deletions in ADNP cause ADNP syndrome (Helsmoortel-Van der Aa syndrome), a neurodevelopmental disorder marked by intellectual disability, autism spectrum disorder traits, motor dysfunction, and developmental delay ADNP is also linked to neurodegenerative diseases, including Alzheimer’s disease, where it modulates tau phosphorylation, amyloid toxicity, and neuronal resilience Dysregulation of ADNP disrupts cell cycle control, proliferation, and apoptosis pathways, leading to impaired neuronal health and cognitive decline ADNP’s broad involvement in transcriptional regulation, synaptic maintenance, and neuroprotection underscores its essential role in brain function, making it a potential therapeutic target for neurodevelopmental and neurodegenerative diseases
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