Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody

Este producto es parte de AMBRA1 - Activating molecule in BECN1-regulated autophagy protein 1
Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

487.5€ (100 µg)

Antibody anti-AMBRA1

proveedor

Abbexa

reference

abx412111

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody is a Rabbit Polyclonal antibody against Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1).


Background

AMBRA1 or Activating Molecule in BECN1-regulated Autophagy Protein 1, is a key regulator of the autophagy process in mammalian cells. Autophagy is a cellular process involved in the degradation and recycling of damaged organelles, misfolded proteins, and other cellular components to maintain cellular homeostasis and respond to stress conditions. AMBRA1 was originally identified as a positive regulator of autophagy that interacts with Beclin 1 (encoded by the BECN1 gene), a core component of the class III phosphatidylinositol 3-kinase (PI3K) complex involved in autophagosome formation. Through its interactions with Beclin 1 and other autophagy-related proteins, AMBRA1 plays a crucial role in initiating and regulating the autophagy process.AMBRA1 interacts with Beclin 1 and helps to stabilize the Beclin 1 complex, promoting the nucleation of autophagosomal membranes and the initiation of autophagy. AMBRA1 regulates the size and maturation of autophagosomes, the double-membrane vesicles that sequester cargo for degradation during autophagy. It interacts with various proteins involved in autophagosome formation and fusion with lysosomes. AMBRA1 is also involved in crosstalk with signaling pathways that regulate autophagy, such as the mammalian target of rapamycin (mTOR) pathway and the p53 pathway. It can be phosphorylated and regulated by these pathways to modulate autophagy in response to cellular stress and nutrient availability.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified


buffer

PBS. Contains sodium azide.


size 1

100 µg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

AMBRA1


dry ice

No


availability

Shipped within 3-7 working days.


alias

AMBRA1,DCAF3,DDB1 and CUL4-associated factor 3


note

This product is for research use only.


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