Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
Pida mas información
935106861
info@markelab.com
Precio
487.5€ (100 µg)
Antibody anti-AMBRA1
proveedor
Abbexareference
abx412111Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody is a Rabbit Polyclonal antibody against Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1).
Background
AMBRA1 or Activating Molecule in BECN1-regulated Autophagy Protein 1, is a key regulator of the autophagy process in mammalian cells. Autophagy is a cellular process involved in the degradation and recycling of damaged organelles, misfolded proteins, and other cellular components to maintain cellular homeostasis and respond to stress conditions. AMBRA1 was originally identified as a positive regulator of autophagy that interacts with Beclin 1 (encoded by the BECN1 gene), a core component of the class III phosphatidylinositol 3-kinase (PI3K) complex involved in autophagosome formation. Through its interactions with Beclin 1 and other autophagy-related proteins, AMBRA1 plays a crucial role in initiating and regulating the autophagy process.AMBRA1 interacts with Beclin 1 and helps to stabilize the Beclin 1 complex, promoting the nucleation of autophagosomal membranes and the initiation of autophagy. AMBRA1 regulates the size and maturation of autophagosomes, the double-membrane vesicles that sequester cargo for degradation during autophagy. It interacts with various proteins involved in autophagosome formation and fusion with lysosomes. AMBRA1 is also involved in crosstalk with signaling pathways that regulate autophagy, such as the mammalian target of rapamycin (mTOR) pathway and the p53 pathway. It can be phosphorylated and regulated by these pathways to modulate autophagy in response to cellular stress and nutrient availability.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified
buffer
PBS. Contains sodium azide.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AMBRA1
dry ice
No
availability
Shipped within 3-7 working days.
alias
AMBRA1,DCAF3,DDB1 and CUL4-associated factor 3
uniprot id
note
This product is for research use only.
Quizá le pueda interesar
anti- AMBRA1 antibody
proveedor
FineTestreference
FNab00356Tested Applications
ELISA, IHC, WBreactivity
human,mouse,ratstatus
RUOclonality
polyclonalWD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino a...
Precio a consultar
Ver másActivating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
proveedor
Abbexareference
abx001006Tested Applications
WB, IHC, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalAMBRA1 Antibody is a Rabbit Polyclonal antibody against AMBRA1. WD-repeats are motifs that are found in a variety of pro...
175€ (20 µl)
Ver másActivating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
proveedor
Abbexareference
abx030158Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalAMBRA1 regulates autophagy and development of the nervous system. This protein is involved in autophagy in controlling p...
281.25€ (80 µl)
Ver más