Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) Antibody
260€ (50 µl)
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Name
Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx212836
Tested Applications
ELISA, IHC
Description
AMBRA1 Antibody is a Rabbit Polyclonal against AMBRA1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) Immunogen: Fusion protein of human AMBRA1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9C0C7 |
| Gene ID | 55626 |
| Alias | AMBRA1,DCAF3,DDB1 and CUL4-associated factor 3 |
| Background | Antibody anti-AMBRA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AMBRA1 or Activating Molecule in BECN1-regulated Autophagy Protein 1, is a key regulator of the autophagy process in mammalian cells. Autophagy is a cellular process involved in the degradation and recycling of damaged organelles, misfolded proteins, and other cellular components to maintain cellular homeostasis and respond to stress conditions. AMBRA1 was originally identified as a positive regulator of autophagy that interacts with Beclin 1 (encoded by the BECN1 gene), a core component of the class III phosphatidylinositol 3-kinase (PI3K) complex involved in autophagosome formation. Through its interactions with Beclin 1 and other autophagy-related proteins, AMBRA1 plays a crucial role in initiating and regulating the autophagy process.AMBRA1 interacts with Beclin 1 and helps to stabilize the Beclin 1 complex, promoting the nucleation of autophagosomal membranes and the initiation of autophagy. AMBRA1 regulates the size and maturation of autophagosomes, the double-membrane vesicles that sequester cargo for degradation during autophagy. It interacts with various proteins involved in autophagosome formation and fusion with lysosomes. AMBRA1 is also involved in crosstalk with signaling pathways that regulate autophagy, such as the mammalian target of rapamycin (mTOR) pathway and the p53 pathway. It can be phosphorylated and regulated by these pathways to modulate autophagy in response to cellular stress and nutrient availability.
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