Actin, smooth muscle / SMA (ACTA2/ACTG2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Actin, smooth muscle / SMA (ACTA2/ACTG2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx341078
tested applications
ELISA, IHC
Description
Actin, smooth muscle / SMA (ACTA2/ACTG2) Antibody is a Mouse Monoclonal antibody for the detection of Human ACTA2/ACTG2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Actin, smooth muscle / SMA (ACTA2/ACTG2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Purification | Purified from ascites by affinity chromatography using specific immunogen. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, containing 0.5% BSA, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P62736, P63267 |
| Alias | ACTSA,α-SMA |
| Background | Antibody anti-ACTA2 |
| Status | RUO |
Descripción
ACTA2 encodes actin alpha 2, a protein that is a key component of the contractile apparatus in smooth muscle cells. Smooth muscle alpha actin is a major component of the contractile apparatus in smooth muscle cells, contributing to the contractility and mechanical properties of various organs and tissues, including blood vessels, airways, and the gastrointestinal tract. ACTA2 (as with all the actins) is extremely highly conserved and found in nearly all mammals Is essential for physiological processes such as blood pressure regulation, airway tone, and peristalsis in the digestive system. It forms filamentous structures that interact with other proteins to generate force and facilitate muscle contraction. Various signaling pathways and transcription factors control the expression of ACTA2, ensuring its proper expression in smooth muscle cells. Mutations or dysregulation of ACTA2 expression have been associated with several smooth muscle-related disorders, including vascular diseases such as thoracic aortic aneurysms and dissections (TAAD), familial thoracic aortic aneurysms and dissections (FTAAD), and other vascular malformations.
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