Actin, smooth muscle / SMA (ACTA2/ACTG2) Antibody

Este producto es parte de ACTA2 - Actin alpha 2 smooth muscle
Actin, smooth muscle / SMA (ACTA2/ACTG2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

260€ (50 µl)

Antibody anti-ACTA2

proveedor

Abbexa

reference

abx341078

Tested Applications

ELISA, IHC

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

Actin, smooth muscle / SMA (ACTA2/ACTG2) Antibody is a Mouse Monoclonal antibody for the detection of Human ACTA2/ACTG2.


Background

ACTA2 encodes actin alpha 2, a protein that is a key component of the contractile apparatus in smooth muscle cells. Smooth muscle alpha actin is a major component of the contractile apparatus in smooth muscle cells, contributing to the contractility and mechanical properties of various organs and tissues, including blood vessels, airways, and the gastrointestinal tract. ACTA2 (as with all the actins) is extremely highly conserved and found in nearly all mammals Is essential for physiological processes such as blood pressure regulation, airway tone, and peristalsis in the digestive system. It forms filamentous structures that interact with other proteins to generate force and facilitate muscle contraction. Various signaling pathways and transcription factors control the expression of ACTA2, ensuring its proper expression in smooth muscle cells. Mutations or dysregulation of ACTA2 expression have been associated with several smooth muscle-related disorders, including vascular diseases such as thoracic aortic aneurysms and dissections (TAAD), familial thoracic aortic aneurysms and dissections (FTAAD), and other vascular malformations.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Actin, smooth muscle / SMA (ACTA2/ACTG2)


host

Mouse


isotype

IgG2a Kappa


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, IHC


purification

Purified from ascites by affinity chromatography using specific immunogen.


recommended dilution

Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, containing 0.5% BSA, 0.02% sodium azide and 50% glycerol.


size 1

50 µl


size 2

100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ACTA2


dry ice

No


availability

Shipped within 5-10 working days.


alias

ACTSA,α-SMA


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