Actin Like Protein 6A (ACTL6A) Antibody
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Description
ACTL6A Antibody is a Rabbit Polyclonal against ACTL6A.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Actin Like Protein 6A (ACTL6A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O96019 |
| Gene ID | 86 |
| Alias | ACTL6,ARPN-BETA,Arp4,BAF53A |
| Background | Antibody anti-ACTL6A |
| Status | RUO |
Descripción
ACTL6A, also known as BAF53A, is a core component of the SWI/SNF chromatin remodeling complex. It interacts with actin-related proteins and histone modifiers to regulate transcriptional activity and chromatin structure. ACTL6A plays a pivotal role in neural development and stem cell maintenance. Structurally, ACTL6A contains an actin-like ATP-binding domain but does not form filaments like traditional actin. Instead, it stabilizes SWI/SNF complexes, enabling precise control over gene expression during differentiation. Mutations or overexpression of ACTL6A have been linked to cancers, particularly gliomas and squamous cell carcinoma, due to its role in regulating proliferation-related genes.
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Involved in transcriptional activation and repression of select genes by chromatin remodeling(alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Component of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
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