Actin Alpha 2, Smooth Muscle (ACTA2) Protein

Este producto es parte de ACTA2 - Actin alpha 2 smooth muscle
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377€ (50 µg)

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935106861
info@markelab.com
name
Actin Alpha 2, Smooth Muscle (ACTA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166376
tested applications
WB, SDS-PAGE

Description

ACTA2 Protein is a recombinant protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Actin Alpha 2, Smooth Muscle (ACTA2)
Host
E. coli
Origin
Human, Mouse, Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 27.6 kDa  Observed MW (SDS-PAGE): 27 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ile167-Phe377

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P62736
Alias
ACTSA,α-SMA
Background
Protein ACTA2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ACTA2 encodes actin alpha 2, a protein that is a key component of the contractile apparatus in smooth muscle cells. Smooth muscle alpha actin is a major component of the contractile apparatus in smooth muscle cells, contributing to the contractility and mechanical properties of various organs and tissues, including blood vessels, airways, and the gastrointestinal tract. ACTA2 (as with all the actins) is extremely highly conserved and found in nearly all mammals Is essential for physiological processes such as blood pressure regulation, airway tone, and peristalsis in the digestive system. It forms filamentous structures that interact with other proteins to generate force and facilitate muscle contraction. Various signaling pathways and transcription factors control the expression of ACTA2, ensuring its proper expression in smooth muscle cells. Mutations or dysregulation of ACTA2 expression have been associated with several smooth muscle-related disorders, including vascular diseases such as thoracic aortic aneurysms and dissections (TAAD), familial thoracic aortic aneurysms and dissections (FTAAD), and other vascular malformations.

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