Actin Alpha 2, Smooth Muscle (ACTA2) Antibody
286€ (40 µl)
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name
Actin Alpha 2, Smooth Muscle (ACTA2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx227123
tested applications
IHC
Description
Actin Alpha 2, Smooth Muscle (ACTA2) Antibody is a Rabbit Monoclonal antibody for the detection of Alpha Smooth Muscle Actin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Actin Alpha 2, Smooth Muscle (ACTA2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IHC-P: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Clone ID | Z996 |
| Purification | Purified from rabbit antiserum by proprietary techniques. |
| Size 1 | 40 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 500 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 20 mg/ml BSA and 0.05% NaN3. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 2-8°C. |
| Dry Ice | No |
| UniProt ID | P62736 |
| Alias | ACTSA,α-SMA |
| Background | Antibody anti-ACTA2 |
| Status | RUO |
Descripción
ACTA2 encodes actin alpha 2, a protein that is a key component of the contractile apparatus in smooth muscle cells. Smooth muscle alpha actin is a major component of the contractile apparatus in smooth muscle cells, contributing to the contractility and mechanical properties of various organs and tissues, including blood vessels, airways, and the gastrointestinal tract. ACTA2 (as with all the actins) is extremely highly conserved and found in nearly all mammals Is essential for physiological processes such as blood pressure regulation, airway tone, and peristalsis in the digestive system. It forms filamentous structures that interact with other proteins to generate force and facilitate muscle contraction. Various signaling pathways and transcription factors control the expression of ACTA2, ensuring its proper expression in smooth muscle cells. Mutations or dysregulation of ACTA2 expression have been associated with several smooth muscle-related disorders, including vascular diseases such as thoracic aortic aneurysms and dissections (TAAD), familial thoracic aortic aneurysms and dissections (FTAAD), and other vascular malformations.
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The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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