Actin Alpha 1, Cardiac Muscle (ACTC1) Antibody
357.5€ (100 µg)
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Name
Actin Alpha 1, Cardiac Muscle (ACTC1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx122378
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACTC1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Actin Alpha 1, Cardiac Muscle (ACTC1) Immunogen: Recombinant fragment corresponding to 44a-269 AA of human ACTC1. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 45 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC009978 |
| Alias | ACTC ASD5,CMD1R,CMH11,LVNC4 |
| Background | Antibody anti-ACTC1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACTC1 encodes for actin alpha 1, a protein that is a crucial component of the contractile apparatus in cardiac muscle cells (cardiomyocytes). It is a major component of the contractile apparatus in cardiac muscle cells, contributing to the contraction and relaxation of the heart. It forms filamentous structures that, along with other proteins such as myosin, tropomyosin, and troponin, make up the sarcomeres—the basic contractile units of cardiac muscle. The contraction of cardiac muscle is regulated by calcium-dependent signaling pathways that modulate the interaction between actin and myosin. During each heartbeat, calcium ions bind to troponin, leading to conformational changes that expose binding sites on actin, allowing myosin to interact and generate force for muscle contraction. The expression of ACTC1 is highly regulated during cardiac development and in response to physiological and pathological stimuli. Mutations in the ACTC1 gene have been associated with various congenital heart diseases, such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), which are characterized by abnormalities in cardiac muscle structure and function
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