Hepatocyte Nuclear Factor 4 Alpha/Gamma Acetyl-Lys127/79 (HNF4A/HNF4G AcK127/79) Antibody
221€ (50 µg)
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Name
Hepatocyte Nuclear Factor 4 Alpha/Gamma Acetyl-Lys127/79 (HNF4A/HNF4G AcK127/79) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx329822
Tested Applications
ELISA, WB
Description
Acetyl-HNF4A/HNF4G (Lys127/79) Antibody is a Rabbit Polyclonal against Acetyl-HNF4A/HNF4G (Lys127/79).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Hepatocyte Nuclear Factor 4 Alpha/Gamma Acetyl-Lys127/79 (HNF4A/HNF4G AcK127/79) Immunogen: Synthetic Acetyl peptide from human protein at AA range: 127 (HNF-4α)/79 (HNF-4γ). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000 - 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41235, Q14541 |
| Alias | TCF,HNF4,MODY,FRTS4,MODY1,NR2A1,TCF14,HNF4a7,HNF4a8,HNF4a9,NR2A21,TCF-14,HNF4alpha,Transcription factor HNF-4,Nuclear receptor subfamily 2 group A member 1 |
| Background | Antibody anti-HNF4A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Hepatocyte nuclear factor 4 alpha (HNF4A) is a critical transcription factor that plays a key role in regulating liver function, metabolism, and the development of the gastrointestinal tract HNF4A is highly expressed in the liver, where it controls the expression of genes involved in hepatic glucose production, lipid metabolism, and bile acid synthesis It also regulates the development and differentiation of liver cells and contributes to maintaining liver homeostasis HNF4A is involved in controlling genes responsible for the metabolism of steroids, carbohydrates, and lipids, and it is crucial for maintaining the liver's metabolic functions Dysregulation of HNF4A has been associated with metabolic diseases, such as diabetes, non-alcoholic fatty liver disease (NAFLD), and liver cirrhosis In addition, mutations in the HNF4A gene can lead to maturity-onset diabetes of the young (MODY), a form of diabetes characterized by early-onset, autosomal dominant inheritance of insulin resistance
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