Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
234€ (5 µg)
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Name
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137271
Description
Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Antibody is a Mouse Monoclonal antibody against Acetyl Coenzyme A Acetyltransferase 1 (ACAT1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase |
| Background | Antibody anti-ACAT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.
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