ABL1 (pY245) Antibody

Descripción

ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

ABL1 (pY245)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, IF/ICC

purification

Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ABL1

dry ice

availability

Shipped within 5-10 working days.

alias

ABL,BCR-ABL,CHDSKM,ABL proto-oncogene 1 non-receptor tyrosine kinase

uniprot id

https://www.uniprot.org/uniprotkb/P00519

gene id

https://www.ncbi.nlm.nih.gov/gene/25

note

This product is for research use only.

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