ABL1 (pY204) Antibody
429€ (100 µl)
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Name
ABL1 (pY204) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx333480
Tested Applications
ELISA, WB
Description
ABL1 (pY204) Antibody is a Rabbit Polyclonal against ABL1 (pY204).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ABL1 (pY204) Immunogen: Peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y (p)-V-S) derived from Human c-Abl. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00519 |
| Alias | ABL,BCR-ABL,CHDSKM,ABL proto-oncogene 1 non-receptor tyrosine kinase |
| Background | Antibody anti-ABL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABL1 is a non-receptor tyrosine kinase involved in various cellular processes, including cytoskeletal remodeling, cell migration, DNA damage response, and signal transduction. It is ubiquitously expressed and localized in both the nucleus and cytoplasm, where it interacts with numerous signaling proteins. ABL1 contains SH2 and SH3 domains, a kinase domain, and regulatory regions that facilitate its interaction with other proteins and its activation in response to cellular stimuli. Dysregulation of ABL1, particularly through chromosomal translocations such as the Philadelphia chromosome, results in the BCR-ABL1 fusion protein, which drives chronic myeloid leukemia (CML) by promoting uncontrolled cell proliferation and survival. Targeting ABL1 with tyrosine kinase inhibitors, such as imatinib, has revolutionized the treatment of CML and highlighted its role as a key therapeutic target. Beyond cancer, ABL1 contributes to cellular responses to oxidative stress, DNA damage repair, and cytoskeletal dynamics, underscoring its importance in maintaining cellular homeostasis and responding to environmental challenges.
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