ABL1 (pY134) Antibody

Descripción

ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

ABL1 (pY134)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, IHC, DB

purification

Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ABL1

dry ice

availability

Shipped within 5-10 working days.

alias

ABL,BCR-ABL,CHDSKM,ABL proto-oncogene 1 non-receptor tyrosine kinase

uniprot id

https://www.uniprot.org/uniprotkb/P00519

gene id

https://www.ncbi.nlm.nih.gov/gene/25

note

This product is for research use only.

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ABL1 (pY412) Antibody

proveedor

Abbexa

reference

abx000351

Tested Applications

IHC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

ABL1 (pY412) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY412). The ABL1 protooncogene encodes a cytoplasmic...

212.5€ (20 µl)