Abhydrolase Domain Containing 12 (ABHD12) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Abhydrolase Domain Containing 12 (ABHD12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432196
tested applications
P-ELISA, WB
Description
ABHD12 Antibody is a Goat Polyclonal antibody against ABHD12.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Abhydrolase Domain Containing 12 (ABHD12) |
| Host | Goat |
| Reactivity | Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 26090, 76192, 499913 |
| NCBI Accession | NP_001035937.1, NP_056415.1 |
| Alias | ABHD12A,BEM46L2,C20orf22,PHARC |
| Background | Antibody anti-ABHD12 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
ABHD12 (Abhydrolase Domain Containing 12) is a membrane-bound serine hydrolase primarily involved in lipid metabolism and neuroinflammatory regulation. It plays a critical role in degrading lysophosphatidylserine (lyso-PS), a bioactive lipid mediator involved in immune signaling. ABHD12 is highly expressed in the brain and other tissues, where it regulates lipid signaling pathways crucial for neural function and homeostasis. Mutations in the ABHD12 gene are associated with PHARC syndrome (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts), a neurodegenerative disorder. This enzyme’s activity is essential for maintaining balanced lipid signaling and protecting against neuroinflammation and neurodegeneration.
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