A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx323278
tested applications
ELISA, WB
Description
ADAMTS2 Antibody is a Rabbit Polyclonal against ADAMTS2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95450 |
| Gene ID | 9509 |
| Alias | PCINP,NPI,ADAM-TS2,Procollagen N-Endopeptidase,ADAMTS-2 |
| Background | Antibody anti-ADAMTS2 |
| Status | RUO |
Descripción
ADAMTS2, also known as A Disintegrin And Metalloproteinase with Thrombospondin Motifs 2, is another member of the ADAMTS protein family ADAMTS2, like other members of the ADAMTS family, contains multiple domains including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS2 is primarily known for its role in collagen processing and extracellular matrix remodeling. It specifically cleaves procollagen molecules, which are precursors to collagen, at specific sites to produce mature collagen molecules. This process is crucial for the proper assembly and organization of collagen fibers in various tissues, including skin, bone, and cartilage. Mutations in the ADAMTS2 gene have been linked to a rare genetic disorder called Ehlers-Danlos syndrome type VIIC (EDS VIIC), also known as dermatosparaxis type EDS. EDS VIIC is characterized by severe skin fragility, joint laxity, and easy bruising due to abnormal collagen processing and structure. These mutations disrupt the enzymatic activity of ADAMTS2, leading to impaired collagen processing and the characteristic symptoms of the disorder.Studies on ADAMTS2 and its role in collagen processing have implications for understanding the pathogenesis of connective tissue disorders like Ehlers-Danlos syndrome and for developing potential therapeutic approaches. Research efforts are focused on elucidating the molecular mechanisms underlying ADAMTS2 function and its regulation in collagen metabolism.
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