A Disintegrin And Metalloprotease 10 (ADAM10) Antibody (FITC)
494€ (100 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
A Disintegrin And Metalloprotease 10 (ADAM10) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270391
Tested Applications
FCM
Description
A Disintegrin And Metalloprotease 10 (ADAM10) Antibody (FITC) is a Rabbit Polyclonal Antibody conjugated to FITC against A Disintegrin And Metalloprotease 10 (ADAM10) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: A Disintegrin And Metalloprotease 10 (ADAM10) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 4°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | MADM, HsT18717,Kuz ,CD156d,AD10,AD18,RAK,KUZ,ADAM-10 |
| Background | Antibody anti-ADAM10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADAM10, also known as ADAM metallopeptidase domain 10, is a type I transmembrane glycoprotein belonging to the ADAM (a disintegrin and metalloproteinase) family of proteins. It is encoded by the ADAM10 gene located on human chromosome 15. ADAM10 plays crucial roles in various biological processes, including cell adhesion, cell fusion, cell signaling, proteolysis, and ectodomain shedding of membrane proteins. It is involved in the cleavage of a wide range of cell surface proteins, including cytokines, growth factors, adhesion molecules, and receptors. ( Notch receptors, amyloid precursor protein (APP), cadherins, and several cytokines and growth factors). The proteolytic activity of ADAM10 is tightly regulated, as its dysregulation can have significant implications in various diseases, including cancer, Alzheimer's disease, inflammation, and cardiovascular diseases. ADAM10-mediated cleavage of Notch receptors is crucial for various developmental processes, and dysregulation of this process has been implicated in cancer and neurodegenerative diseases. ADAM10 has gained significant attention as a potential therapeutic target for various diseases due to its involvement in critical cellular processes and its ability to modulate the activity of numerous substrates. Inhibition or modulation of ADAM10 activity is being explored as a strategy for the treatment of diseases such as cancer, Alzheimer's disease, and inflammatory disorders
Productos relacionados
ADAM Metallopeptidase Domain 10 (ADAM10) Antibody
Rabbit Polyclonal against the ADAM10 protein.…
Ver producto
Human A Disintegrin And Metalloprotease 10 (ADAM10) Protein
Human A Disintegrin And Metalloprotease 10 (ADAM10) Protein is a recombinant Human protein expressed in E. coli.…
Ver producto
Rat A Disintegrin And Metalloprotease 10 (ADAM10) Protein
Rat A Disintegrin And Metalloprotease 10 (ADAM10) protein is a recombinant protein expressed in E. coli.…
Ver producto